OPKO * BioReference Health * Modex

Senior Scientist I- LNP Technology

Job Locations US-MA-WESTON
Requisition Post Information* : Posted Date 2 months ago(5/2/2024 9:37 AM)
Requisition ID
# of Openings
Functional Group
Work Schedule
Monday-Friday 9:00am-5:00pm

Company Overview

This is an exciting time to join our cutting-edge organization! ModeX Therapeutics, an OPKO Health company, is developing the next generation of multi-specific antibodies as novel therapies for cancer and infectious diseases, as well as nanoparticle technologies for the development of next generation vaccines. Join our team of groundbreaking scientists today and change the world tomorrow.​​​​​​​

External Description

ModeX Therapeutics, an OPKO Health Company, is seeking a highly skilled and motivated Senior Scientist with expertise in development of LNP-based therapy to join our team.  The principal responsibilities of his/her role will be to carry out early research project from developing novel ionizable lipids, lipid nanoparticle formulations for antibody conjugation, process development, and to evaluation of novel drug candidate using in vitro assays and in vivo animal models.  The individual will work in the state-of-the-art laboratory and be responsible for experimental planning and execution, data analysis and presentation.  This is an exciting opportunity to be part of a cross-functional team and contribute to the development of next-generation mRNA technology and therapeutics in a fast-paced, rapidly growing biotech company with a bold vision.       


Major responsibilities

  • Interact closely and be part of interdisciplinary research teams to drive the discovery of innovative mRNA/LNP delivery technology and the optimization of their biological and biophysical properties.
  • Leading the effort to develop novel ionizable lipids, LNP formulation and conjugation technologies for in vivo targeted delivery.
  • Develop and implement high-throughput in vitro assays to characterize and evaluate the LNP/mRNA cargo including stability, delivery efficiency, and critical quality attributes.
  • Evaluate the LNP/mRNA formulations in mouse model for specific therapeutic applications.
  • Interpret results and present/communicate with cross-functional colleagues for successful execution and completion of projects.
  • Stay scientifically current and contribute to the implementation of new technology and instrumentation.
  • Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks.



  • Ph.D. or MD with 5 or more years working experiences in ionizable lipid, LNP formulation, mRNA/LNP nanoparticle preparation, mRNA delivery technology, targeted delivery using LNP or Ab conjugated LNP, or related field with excellent track record from academia or industry.
  • Expertise in the development of ionizable lipid, LNP formulation preparation and optimization, mRNA delivery system and experiences in vivo models from mice to NHP are highly desirable. 
  • Hand-on experiences in lipid biology, LNP formulation preparation and optimization, in vitro/in vivo cargo transfer, cell-based in vitro assays, and reporter assays are essential.
  • Excellent written and oral communication, organization, and data analysis skills.  Outstanding learning ability, troubleshooting and problem-solving skills.
  • Highly adaptable to a fast-paced work environment and capable to work independently as well as within project teams.  


The Company

ModeX is a clinical-stage biopharmaceutical company developing next-generation antibodies and vaccines for cancer and infectious disease. ModeX's modular antibody platforms unite the power of multiple biologic components in a single molecule to create multispecific antibodies with greater versatility and potency to fight complex disease than traditional approaches. Our pipeline includes candidates against both solid and liquid tumors as well as several of the world’s most pressing viral threats. Our founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is an OPKO Health Company based in Natick, Massachusetts. For more information see modextx.com.



ModeX Therapeutics is an Equal Opportunity Employer


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